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Are pilot trials useful for predicting randomisation and attrition rates in definitive studies: A review of publicly funded trials.

Author
Abstract
:

External pilot trials are recommended for testing the feasibility of main or confirmatory trials. However, there is little evidence that progress in external pilot trials actually predicts randomisation and attrition rates in the main trial. To assess the use of external pilot trials in trial design, we compared randomisation and attrition rates in publicly funded randomised controlled trials with rates in their pilots.

Year of Publication
:
2018
Journal
:
Clinical trials (London, England)
Number of Pages
:
1740774517752113
Date Published
:
2018
ISSN Number
:
1740-7745
URL
:
http://journals.sagepub.com/doi/abs/10.1177/1740774517752113?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
:
10.1177/1740774517752113
Short Title
:
Clin Trials
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