Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation.
| Author | |
|---|---|
| Abstract |
:
A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities. |
| Year of Publication |
:
2018
|
| Journal |
:
Organic letters
|
| Date Published |
:
2018
|
| ISSN Number |
:
1523-7060
|
| URL |
:
https://dx.doi.org/10.1021/acs.orglett.8b00034
|
| DOI |
:
10.1021/acs.orglett.8b00034
|
| Short Title |
:
Org Lett
|
| Download citation |
