Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma.
| Author | |
|---|---|
| Abstract |
:
Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test drug efficacy and toxicity in vivo for IAC drug discovery. The purpose of this study was to develop a small-animal model of IAC and to analyze the ocular tissue penetration, distribution, pharmacokinetics, and treatment efficacy. |
| Year of Publication |
:
2018
|
| Journal |
:
Investigative ophthalmology & visual science
|
| Volume |
:
59
|
| Issue |
:
1
|
| Number of Pages |
:
446-454
|
| Date Published |
:
2018
|
| ISSN Number |
:
0146-0404
|
| URL |
:
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.17-22302
|
| DOI |
:
10.1167/iovs.17-22302
|
| Short Title |
:
Invest Ophthalmol Vis Sci
|
| Download citation |
