Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window.
| Author | |
| Abstract |
:
Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region. |
| Year of Publication |
:
2012
|
| Journal |
:
Chemical communications (Cambridge, England)
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| Volume |
:
48
|
| Issue |
:
77
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| Number of Pages |
:
9649-51
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| Date Published |
:
2012
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| ISSN Number |
:
1359-7345
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| URL |
:
https://doi.org/10.1039/c2cc33359g
|
| DOI |
:
10.1039/c2cc33359g
|
| Short Title |
:
Chem Commun (Camb)
|
| Download citation |
