In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - a new hope or a blind alley?

In the last decade, the concept of uncharged reactivators potentially able to penetrate the CNS has been introduced as an alternative to the classic charged oxime reactivators. However, this concept brings with it several associated drawbacks such as higher lipophilicity, difficulty in administration, lower affinity to cholinesterases, and higher toxicity risk.